Table 3.

Effect of 30 ligands on TYR activity (X  ± SD, n = 6).

Number	Ligands	TYR activity (U/mL)	Inhibition (%)
	Control	30.33 ± 0.61	0
1	Isorhamnetin-3-O-neohespeidoside	16.82 ± 0.14****	44.42
2	Glabridin	18.45 ± 0.61****	39.01
3	Vitamin C	18.96 ± 0.35****	37.35
4	Asiaticoside	19.11 ± 0.20****	36.86
5	Baicalin	19.66 ± 0.32****	35.02
6	α-Mangostin	20.64 ± 0.30*	31.79
7	Notoginsenoside R1	20.90 ± 0.36	30.92
8	Ginsenoside Rb2	20.99 ± 0.44	30.63
9	Curcumin	21.21 ± 0.45	29.9
10	Salvianolic acid A	21.66 ± 0.50	28.43
11	Isobavachalcone	21.68 ± 0.27	28.36
12	Asperuloside	21.79 ± 0.23	27.32
13	Arbutin	22.07 ± 0.65	27.06
14	Isochlorogenic acid A	22.37 ± 0.19	26.06
15	Ononin	22.46 ± 0.51	25.76
16	Benzene-1,4-diol	22.53 ± 0.34	25.54
17	(EGCG)(-)-Epigallocatechin gallate	22.80 ± 0.27	24.64
18	Hexylresorcinol	22.85 ± 0.30	24.49
19	Neohesperidin	22.94 ± 0.33*	24.19
20	Vitamin E	23.05 ± 0.52**	23.81
21	Silybin	23.22 ± 1.17**	23.25
22	Capsaicin	23.35 ± 0.43***	22.83
23	Tranexamic Acid	23.42 ± 0.16****	22.6
24	Neoandrographolide	23.49 ± 0.31****	22.37
25	Bavachinin A	23.56 ± 0.43****	22.14
26	Melitose	23.74 ± 0.20****	21.54
27	Kojic acid	24.00 ± 0.43****	20.69
28	Procyanidin	24.14 ± 0.31****	20.23
29	Ethyl ferulate	24.16 ± 0.33****	20.16
30	Tea polyphenol	25.26 ± 0.31****	16.52

Compared with the control group, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Compared with arbutin, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, ^####P < 0.0001.