Figure 2.

Scatter plot (top panels) and boxplot (bottom panels) of the disposition index (DI) obtained with the Oral Minimal Model (${\text{DI}}^{\mathrm{MM}}$), exploiting plasma glucose, insulin and C-peptide concentration data, vs. the proposed method (${\text{DI}}^{\mathrm{G}}$), exploiting plasma glucose data only, in dataset 1 (left panels), in the placebo (black triangles) and treatment (grey squares) visits, and in dataset 2, in individuals with the type 2 diabetes (T2D, white squares), pre-diabetes (PD, grey circles) and healthy controls (HC, black triangles). For ${\text{DI}}^{\mathrm{G}}$ calculation model parameters are fixed to T2D population values. Dashed black line represents the diagonal line.