Figure 2.

Striatal l-dopa levels after i.p. injection. (A) Two groups of partially lesioned animals received injections of benz or l-dopa. In the benz group, low levels of l-dopa were recovered on the lesion or the intact sides. Injection of l-dopa caused accumulation of 1.30 pmol/mg of l-dopa on the lesion side above that of benz alone (arrow). (B) When central decarboxylation is blocked for 30 min before killing, 1.2 pmol/mg of l-dopa was recovered on the lesion side (NSD-1015 alone group). l-Dopa injection increased striatal l-dopa to 2.75 pmol/mg. Thus, we estimated that accumulation of 1.51 pmol/mg of l-dopa was induced by the injection (arrow).