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. Author manuscript; available in PMC: 2005 Sep 29.
Published in final edited form as: Circ Res. 2003 Jun 12;93(1):46–53. doi: 10.1161/01.RES.0000080932.98903.D8

Figure 4.

Figure 4

Ratio of integrated reverse-mode to forward-mode NCX driving force during the AP. A, Intrev represents the integral of the Em−ENCX curve from the upstroke of the AP to the NCX RP. Intfor is the integral from the driving-force RP to the point of AP repolarization (taken as the minimum of the NCX driving-force curve). B, Intrev/Intfor increased as a function of [Na+]i and was significantly higher in the failing group. C, Averaged running integrals for all data sets illustrate more rapid reverse-mode NCX activation in myocytes from failing (F) than normal (N) hearts at all levels of [Na+]i. *P<0.05 for normal vs failing myocytes; †P<0.05 for myocytes from failing hearts at 10 mmol/L [Na+]i vs myocytes from normal hearts at 5 mmol/L [Na+]i.