Role of Sodium-Calcium Exchanger in Modulating the Action Potential of Ventricular Myocytes From Normal and Failing Hearts

. Author manuscript; available in PMC: 2005 Sep 29.

Published in final edited form as: Circ Res. 2003 Jun 12;93(1):46–53. doi: 10.1161/01.RES.0000080932.98903.D8

Summary of Statistics for Normal and Failing Hearts

	Normal (N_n=4; n₅=10; n₁₀=12; n₁₅=16)				Failing (N_f=6; n₅=14; n₁₀=12; n₁₅=14)
	E_r, mV	RP, mV	APD₉₀, msec	TTRP_n	E_r, mV	RP, mV	APD₉₀, msec	TTRP_n
5 Na	−86±2	25.8±2.7^*	499.6±53.4	0.137±0.039^*	−81±2	25.7±2.1^*	543.5±33.3^*	0.098±0.022^*
10 Na	−81±1	−20.6±1.2	420.8±29.7	0.896±0.038	−86±2	−22.2±3.5	430.0±23.1	0.804±0.031
15 Na	−85±2	−45±3^*	327.5±22.8^*	0.949±0.053	−85±1	−56.9±1.7^*^†	419.4±17.0^†	0.975±0.014^*

Summary statistics for the resting potential (E_r), driving-force reversal point (RP), action potential duration (APD₉₀), and time-to-RP (TTRP) normalized to the action potential duration (TTRP_n) at 5, 10, and 15 mmol/L [Na⁺]_i of myocytes from normal and failing hearts. N_n and N_f indicate number of normal and failing hearts correspondingly; n₅, n₁₀, and n₁₅, number of myocytes at 5, 10, and 15 mmol/L [Na⁺]_i correspondingly.

Statistically significant difference (P<0.05) between a given parameter and its value recorded at 10 mmol/L [Na⁺]_i.

^†

statistical significance (P<0.05) between normal and failing groups at the same [Na⁺]_i.