TABLE 4.
Comparison of EVs miRNA cargo from different sources of MSCs.
| Source of EVs | Method of EV isolation | miRNA | Function | References |
|---|---|---|---|---|
| MenSCs | MagCapture Exosome isolation kit | let-7 | Cell Cycle and Proliferation, apoptosis and tumor suppression | Sun et al. (2019) |
| UC | miR-21 | Cell Cycle and Proliferation, Apoptosis and Tumor suppression | Wang et al. (2017) | |
| UC | miR-4443 | Inflammation | Ji et al. (2024) | |
| UC | miR-671 | Neuroprotection | Lian et al. (2023) | |
| Filtration/centrifugation combination | let-7a-5p, let-7b-5p, let-7f-5p, let-7c-5p, let-7i-5p, let-7e-5p, let-7g-5p miR-21-5p, miR-126-3p, miR-126-5p, miR-223-3p, miR-103a-3p, miR-486-5p |
Cell Cycle and Proliferation | Marinaro et al. (2019) | |
| miR-143-3p, miR-145-5p, miR-34a-5p, miR-155-5p, miR-203a | Apoptosis and Tumor Suppression | |||
| miR-126-3p, miR-126-5p, miR-221-3p, miR-222-3p | Angiogenesis and Vascular Regulation | |||
| miR-142-3p, miR-142-5p, miR-223-3p, miR-155-5p, miR-451a | Inflammation and Immune Response | |||
| miR-122-5p, miR-425-5p, miR-191-5p | Metabolism and Homeostasis | |||
| miR-125b-5p, miR-125a-5p, miR-23a-3p, miR-23b-3p, miR-26a-5p, miR-26b-5p, miR-30a-5p, miR-30d-5p, miR-30e-5p | Stem Cell Regulation and Differentiation | |||
| BMMSCs | UC | let-7a-5p, let-7e-5p, miR-197-3p, miR-342-3p, miR-99a-5p | Tumor Suppression and Cancer Regulation | Pomatto et al. (2021) |
| miR-483-5p miR-484 |
Inflammation and Immune Response | |||
| miR-130b-3p, miR-199a-3p, miR-365a-3p, miR-365b-3p | Cell Proliferation, Differentiation and Apoptosis | |||
| miR-10b-5p miR-29b-3p miR-483-5p |
Metabolism and Organ Development | |||
| UC | miR-199a-3p miR-23a-3p let-7b-5p let-7a-5p, miR-125b-5p |
Tumor Suppression and Cancer Regulation | Vaka et al. (2023) | |
| miR-155-5p | Inflammation and Immune Response | |||
| miR-877-5p miR-4454 |
Metabolic Regulation and Cellular Homeostasis | |||
| ATMSCs | UC | miR-10a-5p miR-125b-1-3p, miR-126-5p, miR-129-2-3p, miR-136-3p, miR-137, miR-140-5p, miR-144-5p, miR-145-3p miR-148a-3p, miR-148b-5p, miR-149-5p |
Tumor Suppression and Cancer Regulation |
Pomatto et al. (2021)
Xing et al. (2020) |
| miR-142-3p, miR-181a-2-3p | Immune System and Inflammation | |||
| miR-1291 | Metabolism and Drug Resistance | |||
| miR-1226-5p miR-1270 |
Cell Proliferation, Differentiation and Apoptosis | |||
| UCMSCs | UC | miR-21-5p, miR-423-5p | Oncogenic miRNAs and Cancer Progression | Bi et al. (2022) |
| miR-146a-5p | Inflammation and Immune Response | |||
| miR-320a-3p | Cardiovascular and Metabolic Regulation | |||
| let-7i-5p | Tumor Suppression and Cell Cycle Regulation | |||
| UC | miR-125b-5p, and miR-145-5p | Tumor Suppression and Cancer Regulation | Shi et al. (2021) | |
| miR-23a-3p | Cell Proliferation, Apoptosis and Differentiation | |||
| UC | miR-125b, miR-199a-3p, miR-765, miR-28-5p, miR-100-5p | Tumor Suppression and Cancer Regulation | Vaka et al. (2023) | |
| miR-223-3p | Inflammation and Immune Response | |||
| miR23a-3p, miR-4454 | Cellular Homeostasis and Stress Response |