. Author manuscript; available in PMC: 2005 Oct 15.

Published in final edited form as: J Biol Chem. 2005 May 20;280(28):26169–26176. doi: 10.1074/jbc.M502102200

TABLE I.

hLHR construct	Location of mutations	SAS	Constitutive activity^a
		Å²
WT		28	−
L457R	L457^(3.43)R	88	+++
D578N	D578^(6.44)N	29	−
L457R/D578N	L457^(3.43)R/D578^(6.44)N	35	+
L457D	L457^(3.43)D	24	−
D578R	D578^(6.44)R	44	−
L457D/D578R	L457D^(3.43)D/D578^(6.44)R	76	+++
N615R	N615^(7.45)R	43	+
N619R	N619^(7.49)R	23	−
L457R/N615R	L457^(3.43)R/N615^(7.45)R	57	+
L457R/N619R	L457^(3.43)R/N619^(7.49)R	30	+
L457N	L457^(3.43)N	35	−
L457N/N615R	L457^(3.43)N/N615^(7.45)R	55	+
L457N/N619R	L457^(3.43)N/N619^(7.49)R	37	+
L457N/N615R/N619R	L457^(3.43)N/N615^(7.45)R/N619^(7.49)R	50	−

Those mutants that are not constitutively active are denoted by “−” and possess basal activities similar to the WT hLHR. Weakly constitutively active mutants are denoted by “+,” and strongly constitutively active mutants by “+++.”