Table 3.
Association between the APOBa rs676210 genotype and lipid profile outcomes: crude and adjusted estimates with multivariable linear regression.
| Outcome | Crude estimate P valueb | Model 1c adjusted β (SE; 95% CI) | Model 1 P value | Model 2d adjusted β (SE; 95% CI) | Model 2 P value | FDR-Pe |
| HDL-Cf | .03 | –0.157 (0.087; –0.330 to 0.016) | .07 | –0.135 (0.088; –0.310 to 0.040) | .13 | .07 |
| LDL-Cg | <.001 | 0.877 (0.237; 0.403 to 1.352) | <.001 | 0.922 (0.242; 0.439 to 1.405 | <.001 | .002 |
| Non–HDL-C | .03 | 0.673 (0.288; 0.098 to 1.249) | .02 | 0.745 (0.292; 0.162 to 1.328) | .01 | .04 |
| ApoB | .02 | 11.406 (5.163; 1.092 to 21.720) | .03 | 12.490 (5.247; 2.004 to 22.975) | .02 | .04 |
aAPOB: apolipoprotein B.
bCrude P values from unadjusted comparisons between genotype groups.
cModel 1: age, sex, and BMI.
dModel 2: age, sex, BMI, and diabetes.
eFDR-P: false discovery rate–adjusted P value calculated for model 1 comparisons to account for multiple testing.
fHDL-C: high-density lipoprotein cholesterol.
gLDL-C: low-density lipoprotein cholesterol.