Table 6.
Association between APOBa rs676210 alleles and lipid profile outcomes: crude and adjusted estimates with multivariable linear regression.
| Outcome | Crude estimate P valueb | Model 1c adjusted β (SE; 95% CI) | Model 1 P value | Model 2d adjusted β (SE; 95% CI) | Model 2 P value | FDR-Pe |
| HDL-Cf | .05 | –0.091 (0.067; (–0.224 to 0.041) | .17 | –0.075 (0.067; (–0.207 to 0.057) | .26 | .18 |
| LDL-Cg | .004 | 0.606 (0.196; (0.218 to 0.993) | .002 | 0.621 (0.198; (0.230 to 1.012) | .002 | .01 |
| Non–HDL-C | .04 | 0.512 (0.228; (0.061 to 0.963) | .03 | 0.549 (0.229; (0.097 to 1.001) | .02 | .05 |
| ApoB | .02 | 7.601 (4.092; (–0.494 to 15.695) | .07 | 8.202 (4.109; (0.075 to 16.330) | .05 | .09 |
aAPOB: apolipoprotein B.
bCrude P values from unadjusted comparisons between genotype groups.
cModel 1: age, sex, and BMI.
dModel 2: age, sex, BMI, and diabetes.
eFDR-P: false discovery rate–adjusted P value calculated for model 1 comparisons to account for multiple testing.
fHDL-C: high-density lipoprotein cholesterol.
gLDL-C: low-density lipoprotein cholesterol.