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Graphical representation of pairwise alignments of the TbPDE2B catalytic domain with the catalytic domains of one member of each of the known human class I PDEs as well as class I PDEs from Dictyostelium (DdRegA), C. elegans, and T. brucei (TbPDE2A). Catalytic domains were defined by pfam (42). The catalytic domain for the A gene of each of the 11 human PDEs was compared with the catalytic domain of TbPDE2B by blastp (21).
