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. 2002 Apr 2;99(7):4714–4719. doi: 10.1073/pnas.002031599

Figure 4.

Figure 4

Multiple sequence alignment of the TbPDE2B GAF domains to the homologous regions of several other representative PDEs. Part of the total GAF domain defined by pfam (42) is shown. Alignments were made with clustal w and refined manually (31). The columns marked with * or # indicate residues that bind cGMP in the crystal structure of PDE2A (unpublished work) or those recognized as a GAF domain signature motif, respectively (39). Letters after the PDE name, if any, indicate which GAF domain, A or B, is shown. TbPDE2B (T. brucei PDE2B AF192755), TbPDE2A (T. brucei PDE2A, AF263280), and HsPDE5A (Homo sapiens PDE5A, AF043731).