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. Author manuscript; available in PMC: 2005 Sep 29.
Published in final edited form as: Mol Endocrinol. 2005 Apr 14;19(6):1618–1628. doi: 10.1210/me.2004-0503

Figure 2. Over-expression of TRα1 induces myocyte hypertrophy.

Figure 2

a. MOI-dependent effects on protein synthesis by AdTRs. Cells were infected with AdβGal, AdTRα1, AdTRα2, or AdTRβ1 for 48h at the designated MOI. Radiolabeled protein content (RLP) was normalized to AdβGal at identical MOIs and at the 0.3MOI level for the subsequent increases in AdβGal itself. For comparison, the RLP seen with 100nM T3 alone is shown. b. Effects of T3 or GC-1 on protein synthesis. Cells were infected with AdβGal, AdTRα1, AdTRα2, or AdTRβ1 for 48h at 10MOI with various concentrations of T3 or GC-1. Values were normalized to vehicle + AdβGal at 10MOI. c. Effects of AdTRα2 or AdTRβ1 on AdTRα1-induced hypertrophy. Cells were treated with AdTRα1 at 10MOI (□) with the addition of AdTRα2 or AdTRβ1 at the indicated MOIs for 48h.