Figure 8. Interface hubs in (a) ConA (type II) interface and (b) SAP pentraxin (dimeric) interface at Imin=4%.
The proteins are shown in cartoon representation, and each monomer in the dimer is coloured differently. The interface hubs and the residues with which they interact are represented as van der Waals spheres with each residue being coloured differently. The residue name and number are indicated in the Figure, and the chain to which each residue belongs is given within parentheses. Using the one-letter amino acid notation, W88 (A) and Q137 (A) in ConA and K116 (A) in SAP petraxin form the interface hubs. It can be seen from the Figure that these hubs interact with different types of residues from both the chains, thus stabilizing the dimeric interfaces.