Table 3. Interface hubs in various lectin interface types from lectin structure graphs.
Abbreviations: DGL, Dioclea grandiflora (mucana) lectin; PDB, Protein Data Bank.
| Lectin* | PDB code | Interface types in quaternary structure† | Interface hubs (Imin in %)‡ | Imin at which interface cluster is the largest (%) |
|---|---|---|---|---|
| ConA | 2cna | II (canonical)+X2 tetramer | W88A, W88B, Q137A, Q137B (4%) | 6 |
| GS4 | 1gsl | X4 (back-to-back) dimer | R194A, R194B, Y72A, Y72B (4%) | 6 |
| ECoRL | 1axy | X3 (handshake) dimer | I178A, I178B, H180A, H180B (2%) | 4 |
| DBL | 1bjq | II+X1 tetramer | H51A, V57A, R60A, V64A, K116A, N55B, R60B (2%) | 0 |
| DGL | 1dgl | II+X2 tetramer | I187A, I187B (2%) | 0 |
| GS1 | 1hql | X4+unusual tetramer | W10A, W10B (4%) | 0 |
| PNA | 2pel | II+X4+unusual tetramer | N29C, Q33C, E72C, K74C, L219C, R221C, N29D, L219D, R221D (2%) | 0 |
| Galectin-1 | 1a78 | Galectin-1 dimer | L121A, I131A, F90B, F128B (2%) | 0 |
| Galectin-2 | 1uld | Galectin-2 dimer | H96A, Q101A, H96B, Q101B (4%) | 6 |
| Galectin-7 | 2gal | Galectin-7 dimer | R20A, R22A, K98A, R20B, R22B (2%) | 0 |
| Pentraxin (CRP) | 1b09 | Pentraxin pentamer | F199A, K201A, L204A, R118B (2%) | 4 |
| Pentraxin(SAP) | 1gyk | Pentraxin pentamer | K116A (4%) | 4 |
* Galectin-3 (1a3k), Charcot–Leyden protein (1lcl), calreticulin (1gv9), calnexin (1jhn) and arcelin-5 (1ioa) are monomeric types and are not presented here; only one representative from the other dimeric interface types are presented; congerin (1c1f), which has an interface similar to that of galectin-1, is also not presented.
† All the interfaces contributing to the quaternary structure of the lectin are given; the specific interfaces whose hubs are given in the Table are highlighted in bold.
‡ Interface hubs are given at Imin=4%; if no interface hubs were obtained at Imin=4%, those obtained at Imin=2% are given; the one-letter notation for amino acids is used.