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. 2025 Aug 20;30(24):104665. doi: 10.1016/j.jaccas.2025.104665

Visual Summary.

Timeline of the Case
Time Event
X During routine outpatient follow-up after cardiac surgery, marked left ventricular dysfunction, left ventricular dilatation, and elevated levels of BNP levels were found.
X + 4 d On re-evaluation, serum selenium levels were found to be below the detectable limit.
X + 10 d The patient was admitted for further evaluation, including myocardial scintigraphy.
X + 3 wk Endomyocardial biopsy was performed. Selenium supplementation and standard therapy for heart failure were initiated, after which the patient was discharged.
X + 1 mo∼ The clinical course was complicated by multiple episodes of heart failure exacerbation triggered by infections, requiring additional hospitalizations and treatment.
X + 2 y Gradual improvement in echocardiographic findings and BNP levels was observed.
X + 2.5 y BNP levels normalized, although septal asynergy remained evident on echocardiography.
X + 3 y Subsequent imaging, including 123I-BMIPP myocardial scintigraphy, confirmed improvement.
“X” indicates the time point at which selenium deficiency–related cardiomyopathy was first recognized in this patient.
BNP = B-type natriuretic peptide.