Figure 7. Inhibition of binding of collagen I to vWF by A/C-e using the BIAcore™ 3000 system.

(A) Collagen at 0.1 mg/ml was injected over immobilized vWF. (B) Collagen at different concentrations and saturated with A/C-e (450 nM) was injected over immobilized vWF saturated with A/C-e (450 nM). The injection flow rate was 50 μl/min. The arrows indicate the beginning and the end of injections. RU, response units.