Table 2 –
Association between COMT status and median FACT-P, BPI, and FACIT-F scores
| Instrument and category | Median score (interquartile range) |
||||
|---|---|---|---|---|---|
| Baseline | 3 mo | 6 mo | 9 mo | 12 mo | |
| FACT-P | |||||
| COMT rs4680 | 125 (29.2) | 119 (30.4) | 123 (26.6) | 124 (29.9) | 123 (31) |
| COMT wildtype | 124 (26) | 122 (25.8) | 121 (28) | 123 (29) | 122 (28) |
| p value | 0.98 | 0.84 | 0.45 | 0.68 | 0.68 |
| BPI severity | |||||
| COMT rs4680 | 0.75 (2) | 0.5 (2) | 1 (2.5) | 1 (2.75) | 1.5 (2.75) |
| COMT wildtype | 1 (2.5) | 1.25 (2.81) | 1.25 (3) | 1.25 (3.25) | 1.5 (2.75) |
| p value | 0.34 | 0.04 | 0.33 | 0.26 | 0.28 |
| BPI interference | |||||
| COMT rs4680 | 0.43 (1.64) | 0.14 (2.39) | 0.71 (2.89) | 0.64 (2.39) | 0.93 (2.57) |
| COMT wildtype | 0.43 (2) | 0.71 (2.71) | 0.71 (3.14) | 0.86 (3.11) | 0.86 (3) |
| p value | 0.64 | 0.08 | 0.57 | 0.42 | 0.65 |
| FACIT-F | |||||
| COMT rs4680 | 45 (10.9) | 41 (14) | 42 (15) | 43 (12) | 41.4 (14) |
| COMT wildtype | 44 (12) | 41 (15.1) | 43 (14) | 43 (13) | 42 (16) |
| p value | 0.50 | 0.58 | 0.69 | 0.84 | 0.88 |
BPI = Brief Pain Inventory; FACIT-F = Functional Assessment of Chronic Illness Therapy-Fatigue; FACT-P = Functional Assessment of Cancer Therapy-Prostate.