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. 2025 Jun 6;5(4):665–693. doi: 10.1021/acsbiomedchemau.5c00070

2. Structure–Activity Relationship of Endo-S-2′3′-CDNs Varying Both Nucleobases and Ribose Substitution.

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a

Thermal shift assay to determine STING binding.

b

Fluorescence polarization assay to determine binding affinity for analogs to STING.

c

Reporter assay in THP1 cells to determine EC50 values.

d

Reporter assay in RAW cells to determine EC50 values.