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| Compound | IC50 (μM) | IC50 of metformin in combination (MET/BQAC 50:1) (μM) | Combination index |
|---|---|---|---|
| Metformin | 987± 10 | ||
| 8a | 2.2 | 59 ± 9 | 0.59 |
| 9a | 5.0 | 106 ± 5 | 0.53 |
| 11a | 2.0 | 40 ± 5 | 0.44 |
| 26 | 6.6 | 105 ± 10 | 0.43 |
| 31 | 1.8 | 32 ± 5 | 0.39 |
