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. 2024 Dec 26;5(4):284–292. doi: 10.1021/acsnanoscienceau.4c00066

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© 2024 The Authors. Published by American Chemical Society

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Evaluation of the synergistic effect by concurrent treatment of siAR and mPTEN LNPs in C4-2 cells. (A, B) Dose-responsive cell viability of PCa cells after treatment with (A) siAR LNPs and (B) mPTEN LNPs at varying concentrations. (C) Cell viability following cotreatment with siAR and mPTEN LNPs at different siAR concentrations (5, 10, 20, and 40 nM) combined with different mPTEN concentrations (62.5, 125, 250, and 500 ng/mL). (D) Heatmap showing CI values for different combinations of mPTEN and siAR, with values below 1 indicating synergistic effects and values below 0.5 indicating strong synergy. (E) Comparison of f _additive and f _combination values. ns, no significant difference; *, p < 0.05; **, p < 0.01; and ***, p < 0.001 (n = 4).