Fig. 2. (A) Simulation snapshots showing the typical 3D arrangement of the chromatin filament and TF cluster structure (insets) at low silencing probability (ps = 10−4). Panels (i), (ii) and (iii) refer to the three silencing mechanisms assumed in the models (positive, negative and neutral feedback respectively). (B) Typical simulation snapshots for the positive, negative and neutral feedback ((i)–(iii)) at high silencing probability (ps = 0.05 in (i) and (iii), ps = 0.1 in (ii)). (C) Average size of clusters formed by active TFs over time for the the positive (panel (i)), negative (panel (ii)) and neutral (panel (iii)) feedback models. The darker the curve, the higher the silencing probability ps it represents.
