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. 2025 Aug 8;15:1608664. doi: 10.3389/fonc.2025.1608664

Figure 2.

A multi-panel image depicting genomic data analysis. Panel A is a protein domain structure with mutation types such as missense, truncating, and splice, shown on a linear protein diagram. Panel B is a heatmap displaying various genetic alterations across different samples, annotated with age, gender, sample type, stage, TMB, MSI, and tumor grade. Panel C and D are dot plots indicating gene set enrichment analysis, with fold enrichment and color-coded significance. Panel E is a bar graph summarizing mutation frequencies in genes associated with specific signaling pathways, highlighting differences between RNF43 codon 659 mutated and non-mutated groups.

A panoramic analysis of the genomic and pathway characteristics of RNF43-mutated in CRC. (A) Lollipop plots (maps mutations on a linear protein and its domains) in this study. Truncating includes frameshift mutations and nonsense mutations. (B) Top 50 mutation spectrum in 283 RNF43-mutated patients. Each column represents a patient, and each row represents a gene. The table on the left represents the mutation rate of each gene. The top plot represents the overall number of mutations a patient carried. Different colors denote different types of mutations. KEGG (C) and GO (D) functional enrichment analyses of RNF43-mutated. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes. (E) The differences in core gene mutation of major signaling pathways (PI3K-Akt signaling pathway, MicroRNAs pathway, DNA damage repair, and tumor suppressor genes) between RNF43 codon 659-mutated and RNF43 Non-codon 659-mutated. CRC, Colorectal cancer; *p<0.05; **p<0.01; ***p<0.001.