Table 2.
Clinicopathological and molecular characteristics of RNF43 codon 659-mutated and RNF43 Non-codon 659-mutated.
| Clinicopathologic characteristics | Number of patients, N (%) (N=282) | RNF43 codon 659-mutated, N (%) (N=118) | RNF43 Non-codon 659-mutated, N (%) (N=164) | P value |
|---|---|---|---|---|
| Age (median 57.94, range 13–95) | 0.2249 | |||
| Young (years <50) | 83 (29.43%) | 30 (25.42%) | 53 (32.32%) | |
| Intermediate (<70 years ≥50) | 103 (36.52%) | 41 (34.75%) | 62 (37.80%) | |
| Elder (years≥70) | 95 (33.69%) | 46 (38.98%) | 49 (29.88%) | |
| NA | 1 (0.35%) | 1 (0.85%) | 0 (0.00%) | |
| Gender | 0.1343 | |||
| Female | 149 (52.84%) | 60 (50.85%) | 89 (54.27%) | |
| Male | 118 (41.84%) | 48 (40.68%) | 70 (42.68%) | |
| NA | 15 (5.32%) | 10 (8.47%) | 5 (3.05%) | |
| Primary tumor location | <0.0001 | |||
| Right | 147 (52.13%) | 70 (59.32%) | 77 (46.95%) | |
| Left | 69 (24.47%) | 13 (11.02%) | 56 (34.15%) | |
| NA | 66 (23.40%) | 35 (29.66%) | 31 (18.90%) | |
| TNM stage | 0.0124 | |||
| I | 38 (13.48%) | 12 (10.17%) | 26 (15.85%) | |
| II | 91 (32.27%) | 43 (36.44%) | 48 (29.27%) | |
| III | 77 (27.30%) | 35 (29.66%) | 42 (25.61%) | |
| IV | 56 (19.86%) | 15 (12.71%) | 41 (25.00%) | |
| NA | 20 (7.09%) | 13 (11.02%) | 7 (4.27%) | |
| TUMOR_GRADE | ||||
| Well differentiated | 45 (15.96%) | 14 (11.86%) | 31 (18.90%) | 0.0196 |
| Moderately differentiated | 63 (22.34%) | 19 (16.10%) | 44 (26.83%) | |
| Moderate poorly differentiated | 10 (3.55%) | 3 (2.54%) | 7 (4.27%) | |
| Poorly differentiated | 58 (20.57%) | 26 (22.03%) | 32 (19.51%) | |
| NA | 106 (37.59%) | 56 (47.46%) | 50 (30.49%) | |
| TMB | <0.0001 | |||
| TMB-H | 198 (70.21%) | 110 (93.22%) | 88 (53.66%) | |
| TMB-L | 67 (23.76%) | 2 (1.69%) | 65 (39.63%) | |
| NA | 17 (6.03%) | 6 (5.08%) | 11 (6.71%) | |
| MSI | <0.0001 | |||
| MSI-H | 138 (48.94%) | 93 (78.81%) | 45 (27.44%) | |
| MSS | 92 (32.62%) | 2 (1.69%) | 90 (54.88%) | |
| NA | 52 (18.44%) | 23 (19.49%) | 29 (17.68%) | |
| BRAF status | 0.2519 | |||
| BRAF mut | 96 (34.04%) | 45 (38.14%) | 51 (31.10%) | |
| BRAF wild-type | 186 (65.96%) | 73 (61.86%) | 113 (68.90%) | |
| BRAF mutation types | 0.3272 | |||
| Class 1 | 86 (30.50%) | 42 (35.59%) | 44 (26.83%) | |
| Class 2 | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | |
| Class 3 | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | |
| NA | 10 (3.55%) | 3 (2.54%) | 7 (4.27%) |