Figure 5. Forest Plot Showing the Effects of WMHVR on Hippocampal Atrophy Rate, While Accounting for the Effects of APOE-ε4 Status and Aβ in Separate Models.

Forest plot showing coefficients and 95% CIs for the influence of WMHVR and additional neurologic variables of interest in separate models on HAR as the outcome. The coefficient reflects the difference in hippocampal atrophy rate (mL/y) associated with levels of independent variables stated in brackets. All models were adjusted for sex, age at baseline, and TIV. Dashed horizontal lines separate the different models. The sample size for each model is determined by the N for each additional independent variable given in Table 1. BL = baseline assessment; CL = Centiloid; HAR = hippocampal atrophy rate; NfL = neurofilament light chain; TIV = total intracranial volume; WMHV = white matter hyperintensity volume; WMHVR = WMHV change rate.