Table 1.
Linear Regression Models to Test the Influence of WMHVR and Additional Variables of Interest on HAR as an Outcome
| Model | Independent variables | N |
| 1.1 | WMHVR | 317 |
| 1.2 | WMHVR + WB BSI | 317 |
| 2.1.1 | WMHVR + SBP age 36 (seated) | 286 |
| 2.1.2 | WMHVR + DBP age 36 (seated) | 286 |
| 2.2.1 | WMHVR + SBP age 43 (seated) | 303 |
| 2.2.2 | WMHVR + DBP age 43 (seated) | 303 |
| 2.3.1 | WMHVR + SBP age 53 (seated) | 310 |
| 2.3.2 | WMHVR + DBP age 53 (seated) | 310 |
| 2.4.1 | WMHVR + SBP age 60–64 (seated) | 317 |
| 2.4.2 | WMHVR + DBP age 60–64 (seated) | 317 |
| 2.5.1 | WMHVR + SBP age 69 (seated) | 315 |
| 2.5.2 | WMHVR + DBP age 69 (seated) | 315 |
| 2.6.1 | WMHVR + SBP age 70–73 (lying) | 315 |
| 2.6.2 | WMHVR + DBP age 70–73 (lying) | 315 |
| 2.7.1 | WMHVR + SBP age 70–73 (standing) | 315 |
| 2.7.2 | WMHVR + DBP age 70–73 (standing) | 315 |
| 3.1 | WMHVR + FHS-CVS age 36 | 286 |
| 3.2 | WMHVR + FHS-CVS age 53 | 309 |
| 3.3 | WMHVR + FHS-CVS age 69 | 312 |
| 4 | WMHVR + APOE-ε4 status | 316 |
| 5 | WMHVR + baseline (phase 1) Aβ CL score | 311 |
Abbreviations: Aβ = β-amyloid; CL = Centiloid; DBP = diastolic blood pressure; FHS-CVS = Framingham Heart Study Cardiovascular Risk Score; HAR = hippocampal atrophy rate; NfL = neurofilament light chain; SBP = systolic blood pressure; TIV = total intracranial volume; WB BSI = whole-brain boundary shift integral; WMHV = white matter hyperintensity volume; WMHVR = WMHV change rate.
Covariates sex, age, and TIV were included in all models, and all models had HAR as the dependent variable. All independent variables and covariates were included as an interaction term with scan interval. Huber and White robust standard errors were used in all models. The same variables were further accounted for in semipartial R2 analysis, again in separate models.