TABLE 3.
Odds of mortality among IBD patients hospitalised with VTE
| Variable | Unadjusted OR (95% CI) |
Adj. ORa
(95% CI) |
|---|---|---|
| Age in years | ||
| <18 | – | – |
| 18–30 | 1.00 (Reference) | 1.00 (Reference) |
| 31–40 | 1.26 (0.82, 1.94) | 0.98 (0.85, 1.12) |
| 41–50 | 1.63 (1.10, 2.42) | 1.02 (0.89, 1.16) |
| 51–65 | 2.97 (2.09, 4.24) | 1.11 (0.98, 1.25) |
| 66–80 | 4.60 (3.23, 6.55) | 1.10 (0.96, 1.27) |
| >80 | 5.56 (3.84, 8.06) | 1.29 (1.09, 1.52) |
| Sex | ||
| Female | 1.00 (Reference) | 1.00 (Reference) |
| Male | 1.05 (0.94, 1.18) | 1.14 (1.08, 1.20) |
| IBD subtype | ||
| Crohn’s disease | 1.00 (Reference) | 1.00 (Reference) |
| Ulcerative colitis | 1.48 (1.32, 1.66) | 1.02 (0.96, 1.09) |
| Indeterminate colitis | 1.71 (0.92, 3.17) | 0.96 (0.67, 1.38) |
| Race | ||
| Non-Hispanic White | 1.00 (Reference) | 1.00 (Reference) |
| Non-Hispanic Black | 1.05 (0.87, 1.26) | 1.03 (0.93, 1.15) |
| Hispanic | 1.43 (1.11, 1.84) | 1.22 (1.03, 1.43) |
| Other | 1.06 (0.76, 1.49) | 1.23 (1.01, 1.48) |
| Unknown | 0.67 (0.56, 0.82) | 1.10 (0.99, 1.22) |
| Median household zip code income quartile | ||
| Highest | 1.00 (Reference) | 1.00 (Reference) |
| High | 1.08 (0.92, 1.25) | 0.97 (0.89, 1.05) |
| Low | 1.08 (0.92, 1.26) | 0.95 (0.87, 1.03) |
| Lowest | 1.14 (0.97, 1.33) | 0.98 (0.90, 1.07) |
| Missing | 1.26 (0.85, 1.87) | 0.88 (0.70, 1.11) |
| Insurance status | ||
| Private | 1.00 (Reference) | 1.00 (Reference) |
| Medicare | 2.31 (2.01, 2.67) | 1.21 (1.11, 1.32) |
| Medicaid | 1.35 (1.06, 1.71) | 1.07 (0.96, 1.19) |
| Self-pay | 1.62 (1.14, 2.30) | 1.02 (0.85, 1.21) |
| No charge | 2.79 (1.28, 6.08) | 1.00 (0.62, 1.63) |
| Other | 1.39 (0.94, 2.06) | 1.04 (0.87, 1.25) |
| Malignancy | ||
| No | 1.00 (Reference) | 1.00 (Reference) |
| Yes | 1.97 (1.63, 2.38) | 0.92 (0.81, 1.04) |
| Clostridioides difficile | ||
| No | 1.00 (Reference) | 1.00 (Reference) |
| Yes | 2.93 (2.51, 3.44) | 1.63 (1.42, 1.86) |
| Comorbidities | ||
| None | 1.00 (Reference) | 1.00 (Reference) |
| One | 1.06 (0.90, 1.26) | 0.95 (0.87, 1.03) |
| ≥2 | 1.1 (0.95, 1.28) | 0.92 (0.85, 1.00) |
| Chronic corticosteroid use | ||
| No | 1.00 (Reference) | 1.00 (Reference) |
| Yes | 0.54 (0.4, 0.74) | 1.03 (0.92, 1.17) |
| Chronic anticoagulation use | ||
| No | 1.00 (Reference) | 1.00 (Reference) |
| Yes | 0.40 (0.31, 0.51) | 1.08 (0.99, 1.19) |
| Colorectal surgery | ||
| No | 1.00 (Reference) | 1.00 (Reference) |
| Yes | 2.18 (1.84, 2.58) | 1.22 (1.08, 1.38) |
| Flex sig/colonoscopy | ||
| No | 1.00 (Reference) | 1.00 (Reference) |
| Yes | 1.01 (0.7, 1.35) | 1.41 (1.20, 1.67) |
| Year | ||
| 2000–2004 | 1.00 (Reference) | 1.00 (Reference) |
| 2005–2009 | 1.07 (0.88, 1.29) | 0.76 (0.68, 0.85) |
| 2010–2014 | 1.35 (1.13, 1.61) | 0.57 (0.51, 0.63) |
| 2014–2018 | 1.34 (1.12, 1.60) | 0.54 (0.48, 0.60) |
a
Adjusted for all variables listed in the table.
Abbreviations: Adj., Adjusted; CI, Confidence Interval; Flex Sig, Flexible Sigmoidoscopy; IBD, Inflammatory Bowel Disease; OR, Odds Ratio; VTE, Venous Thromboembolism.