Table 2.

An information card for IL-6, an extract from the summary table ( Supplementary Table S1 ).

Entity	Value
Name	IL-6
HGNC Name	IL6
UniProt	UniProt:P05231
Category	Soluble
Key events	2, 3, 4
Modulation	Increase of activity
Source cells	Monocytes, macrophages, endothelial cells
Biological consequence	Leads to systemic inflammation, pyrogenic, promotes T effector cell differentiation, promotes CRP and fibrinogen production from hepatocytes
Target cells	Bystander T cells, monocytes, macrophages, hepatocytes
Receptors	IL6R (UniProt:P08887), IL6ST (UniProt:P40189)
References	PMID:27381687, PMID:29387417, PMID:27076371

The ‘entity’ elements in this table correspond to the columns of Supplementary Table S1 (Name, HGNC Name, etc.). The main purpose of this table is to identify molecules, assign them to the relevant events of the AOP network, determine the source and target cell types, show the corresponding receptors, as well as define the role of molecules in the adverse outcome mechanisms (biological consequence). Databases: HGNC, HUGO Gene Nomenclature Committee, https://www.genenames.org; UniProt, https://www.uniprot.org. IL-6, interleukin 6; UniProt, Universal Protein Resource; IL6R, interleukin 6 receptor; IL6ST, interleukin 6 signal transducer; PMID, PubMed Identifier.