Skip to main content
. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: Cancer Res. 2025 Sep 15;85(18):3378–3398. doi: 10.1158/0008-5472.CAN-24-3037

Figure 2. Overview of CAF subtypes.

Figure 2.

A: Schematic showing cell(s) of origin, phenotype and/or function, markers and/or gene signature, and prognosis associated with each CAF subtype. B: Summary of CAF subtypes identified in different tumor types, markers and/or gene signature, and prognosis associated with each subtype. proCAF: progenitor CAF; myCAF: myofibroblast CAFs; senCAF: senescent CAF; mCAF: matrix-producing CAF; iCAF: inflammatory CAF; apCAF: antigen-presenting CAF; pan-dCAF: pan-desmoplastic CAF; pan-pCAF: pan-proliferating CAF ; CAFadi: adipogenic CAF; CAFpn: peripheral-nerve like CAF; ifnCAF: interferon-response CAF; rCAF: reticular-like CAF; tCAF: tumor-like CAF; csCAF: complement-secreting CAF; dCAF: developmental CAF; vCAF: vascular CAF; cCAF: cycling CAF; eCAF: EMT-like CAF. Created in BioRender. Flynn, J. (2025) https://BioRender.com/fu3j89k