Figure 1: Cardiac dysfunction in BPH/2J mice prior to hypertension is followed by sex-dependent HF-like development in later life.

The SBP and HR values of male (A and B) and female (C and D), respectively, in BPN/3J and BPH/2J mice were analyzed by left carotid artery catheterization (1% isoflurane) at 6 weeks and 1.5 years of age. Representative short-axis view on M-mode of the LV (E) from male and female mice analyzed by echocardiography (1% isoflurane). LVEF in male (F) and female (G) mice. LVFS in male (H) and female (I) mice. Data are presented as mean ± SEM. *different from BPN/3J 6-week-old; #different from BPN/3J 1.5-year-old; **different from BPH/2J 6-week-old (p<0.05).