Table 1.
Difference of characteristics between the patients with non-MCI and MCI
| Characteristics | non-MCI (n = 128) |
MCI (n = 115) |
p value |
|---|---|---|---|
| Age, years | 65.0 ± 8.4 | 69.3 ± 7.0 | < 0.001 |
|
Gender, male/female Education (years) BMI, kg/m2 Smoking Alcohol intake > 30 g/day |
62/66 8.0 (8.0–11.0) 25.0 (22.9–26.4) 31 (24.2%) 28 (21.9%) |
61/54 9.0 (8.0–11.0) 25.0 (23.5–26.7) 26 (22.6%) 20 (17.4%) |
0.473 0.919 0.449 0.767 0.381 |
|
Hypertension Diabetes mellitus |
89 (69.5%) 52 (40.6%) |
75 (65.2%) 42 (36.5%) |
0.474 0.512 |
| Coronary artery disease | 22 (17.2%) | 15 (13.0%) | 0.369 |
| Atrial fibrillation | 12 (9.4%) | 8 (7.0%) | 0.493 |
| Initial SBP, mmHg | 138.1 ± 16.3 | 137.6 ± 16.3 | 0.810 |
| Initial DBP, mmHg | 81.0 (74.0–90.0) | 80.0 (72.0–90.0) | 0.395 |
| Hemoglobin, g/L | 135.9 ± 10.2 | 134.5 ± 11.0 | 0.309 |
| CRP, mg/L | 0.7 (0.5–2.4) | 0.9 (0.5–3.5) | 0.352 |
| Fibrinogen, g/L | 3.0 ± 0.8 | 2.9 ± 0.9 | 0.386 |
| ALT, U/L | 19.0 (14.0–23.0) | 21.0 (14.0-24.6) | 0.228 |
| AST, U/L | 18.0 (14.0-22.3) | 19.0 (14.0–23.0) | 0.162 |
| Initial glucose, mmol/L | 6.7 (5.5–8.3) | 6.5 (5.5–7.9) | 0.518 |
| TC, mmol/L | 4.2 ± 1.2 | 4.5 ± 1.3 | 0.130 |
| LDL-C, mmol/L | 2.5 (1.8-3.0) | 2.6 (2.2–3.2) | 0.118 |
|
Creatinine, µmol/L BUN, mmol/L |
62.0 (55.0–78.0) 5.6 (4.6–6.1) |
66.0 (55.0–82.0) 5.6 (4.6–6.6) |
0.207 0.531 |
| eGFR, mL/min per 1.73 m2 | 90.5 (87.0-96.7) | 90.9 (86.5–98.3) | 0.411 |
| MoCA score | 26 (26–28) | 23 (21–24) | < 0.001 |
| MMSE score | 28 (27–29) | 27 (26–28) | < 0.001 |
| AVLT-IR score | 5.7 ± 1.4 | 4.7 ± 1.4 | < 0.001 |
| AVLT-20 min DR score | 5 (4–6) | 3 (2–5) | < 0.001 |
| TMT-A, sec | 62 (50–80) | 89 (72–121) | < 0.001 |
| Stroop-A, sec | 31 (26–42) | 32 (28–42) | 0.002 |
| Stroop-B, sec | 51 (41–65) | 60 (48–77) | < 0.001 |
| TMT-B, sec | 160 (135–196) | 243 (208–320) | < 0.001 |
| Stroop-C, sec | 92 (76–112) | 118 (97–180) | < 0.001 |
| DST (backward) score | 4 (4–5) | 4 (3–4) | 0.003 |
| CDT score | 9 (8–9) | 8 (7–9) | < 0.001 |
Abbreviations: MCI, mild cognitive impairment; BMI, body mass index; SBP, systolic blood pessure; DBP, diastolic blood pressure; CRP, C-reactive protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; LDL-C, low density lipoprotein cholesterol; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; MoCA, montreal cognitive assessment; MMSE, mini-mental state examination; AVLT-IR, auditory verbal learning test-immediate recall; AVLT-20 min DR, auditory verbal learning test-20-min delayed recall; TMT-A, trail making tests A; Stroop-A, stroop color and word test A; Stroop-B, stroop color and word test B; TMT-B, trail making tests B; Stroop-C, stroop color and word test C; DST, digit span test; CDT, clock drawing test