Table 2.
Relationship between TMAO levels and MCI
| TMAO level, µmol/L | OR (95% CI) | |||
|---|---|---|---|---|
| Unadjusted | P value | Adjusteda | P value | |
| Continuous TMAO level | ||||
| < 4.74 | 1 | 1 | ||
| ≥ 4.74 | 5.256 (2.922–9.455) | < 0.001 | 5.745 (2.913–11.328) | < 0.001 |
| Quartile of TMAO level | ||||
| 1 (< 2.10) | 1 | 1 | ||
| 2 (2.10–3.66) | 2.386 (1.115–5.108) | 0.025 | 2.736 (1.156–6.478) | 0.022 |
| 3 (3.67–5.53) | 2.549 (1.192–5.451) | 0.016 | 3.021 (1.227–7.435) | 0.016 |
| 4 (> 5.53) | 6.563 (2.967–14.517) | < 0.001 | 6.953 (2.741–17.638) | < 0.001 |
Abbreviations: TMAO, trimethylamine N-oxide; MCI, mild cognitive impairment; CI, confidence interval
a Adjusted for age, gender, education, body mass index, smoking, drinking, hypertension, diabetes mellitus, coronary artery disease, atrial fibrillation, initial systolic blood pressure, initial glucose, low density lipoprotein cholesterol and eGFR