Table 7.
Effect size of AIP on incident diabetes in prespecified and exploratory subgroups
| Characteristic | No of participants | HR (95%CI) | P value | P for interaction |
|---|---|---|---|---|
| Age(years) | 0.0003 | |||
| 20 to <45 | 75,643 | 2.868 (2.125, 3.871) | <0.001 | |
| 45 to <60 | 36,278 | 2.789 (2.194, 3.546) | <0.001 | |
| ≥60 | 16,015 | 1.414 (1.071, 1.867) | <0.001 | |
| Gender | 0.7097 | |||
| Male | 68,233 | 2.265 (1.882, 2.726) | <0.001 | |
| Female | 59,703 | 2.416 (1.814, 3.219) | <0.001 | |
| BMI (kg/m2) | 0.0111 | |||
| <18.5 | 7561 | 2.322 (0.437, 12.334) | 0.323 | |
| ≥18.5, <24 | 72,305 | 3.416 (2.616, 4.462) | <0.001 | |
| ≥24, <28 | 38,156 | 2.474 (1.963, 3.117) | <0.001 | |
| ≥28 | 9914 | 1.678 (1.213, 2.322) | 0.002 | |
| Smoking status | 0.1639 | |||
| Non-smoker | 98,587 | 2.192 (1.799, 2.672) | <0.001 | |
| Smoker | 29,349 | 2.698 (2.143, 3.396) | <0.001 | |
| Drinking status | 0.1786 | |||
| Non-drinker | 98,676 | 2.234 (1.859, 2.686) | <0.001 | |
| Drinker | 29,260 | 2.747 (2.129, 3.544) | <0.001 | |
| SBP (mmHg) | 0.0401 | |||
| <140 | 115,579 | 2.601 (2.174, 3.111) | <0.001 | |
| ≥140 | 12,357 | 1.810 (1.340, 2.446) | <0.001 | |
| DBP (mmHg) | 0.7979 | |||
| <90 | 117,813 | 2.368 (1.996, 2.809) | <0.001 | |
| ≥90 | 10,123 | 2.492 (1.748, 3.553) | <0.001 | |
| Country | 0.1974 | |||
| Chinese | 112,483 | 1.862 (1.558, 2.227) | <0.001 | |
| Japanese | 15,453 | 2.423 (1.686, 3.481) | <0.001 |
Note 1: Above model was adjusted for age, gender, BMI, SBP, DBP, FPG, LDL-c, ALT, AST, smoking, and drinking status
Note 2: In each case, the model is not adjusted for the stratification variable