Table 2.

Logistic regression analysis

	Total cohort				Subcohort with two recurrences of CDI
	Univariable analysis		Multivariable analysis		Univariable analysis		Multivariable analysis
	Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value
Age	1 (0.99–1.02)	0.91			1.02 (0.99–1.05)	0.29
Female	1.2 (0.72–2.01)	0.49			1.06 (0.49–2.31)	0.88
Hospitalized last 90 days	0.95 (0.55–1.63)	0.85			1.21 (0.54–2.73)	0.64
Clinical Frailty Scale 4–9	0.76 (0.41–1.4)	0.37			2.92 (1.16–7.32)	0.02	2.92 (1.11–7.67)	0.03
Charlson Comorbidity Index	0.98 (0.88–1.1)	0.76			1.16 (0.98–1.39)	0.09
Healthy	1.44 (0.69–2.99)	0.33			0.31 (0.1–1.01)	0.05
Kidney failure GFR < 30	1.01 (0.4–2.59)	0.98			3.31 (0.78–14.04)	0.1	3.89 (0.8-18.85)	0.09
Cerebrovascular disease	0.37 (0.18–0.76)	0.01	0.39 (0.19–0.81)	0.01	1.08 (0.32–3.65)	0.9
Immunosuppression	1.82 (0.91–3.64)	0.09	1.61 (0.79–3.29)	0.19	0.92 (0.37–2.27)	0.86
Carbapenems	0.9 (0.33–2.49)	0.84			5.05 (0.97–26.31)	0.05	5.09 (0.78–33.27)	0.09
Hospitalized for 1st CDI	0.5 (0.28–0.88)	0.02	0.54 (0.3–0.96)	0.02	0.73 (0.38–1.59)	0.43
Days between 1st and 2nd recurrence of CDI					0.96 (0.93-1)	0.03	0.95 (0.92–0.99)	0.02
C-reactive protein (mg/L) at 2nd recurrence					0.99 (0.98-1)	0.02

Regression analyses for total cohort (one versus more than one recurrence) and the subcohort (two versus more than two recurrences). The predictors Healthy and Charlson Comorbidity Index were excluded from the multivariable analysis due to collinearity with Clinical Frailty Scale regarding a person’s general health and symptoms of chronic conditions. Age, sex and previous hospitalization are reported in the univariable analysis since they are previously described risk factors for recurrence. C-reactive protein (mg/L) at 2nd recurrence was excluded from the multivariable analysis due to a high extent of missing values (47%)

CI Confidence Interval, GFR Glomerular Filtration Rate (mL/min/1.73 m²), CDIClostridioides difficile infection