Fig. 25.

Schematic of AHA@MnP/QCT nanoparticle preparation and its one-stone-for-two-birds strategy for integrated diagnosis and treatment of non-small cell lung cancer. The AHA@MnP/QCT NP vector sustainably releases QCT and Mn²⁺ in the acidic tumor environment, inducing apoptosis and promoting ferroptosis via Fenton-like reactions. Free Mn²⁺ induces immunogenic cell death by activating DCs and promoting T cell activation and proliferation. Non-invasive imaging is achieved through tumor accumulation of AHA@MnP/QCT, enhancing the T₂-MRI signal at the tumor site