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. 2025 Aug 22;44:249. doi: 10.1186/s13046-025-03520-6

Table 1.

Overview of nanoparticles activate cGAS-STING to induce ferroptosis in cancer treatment

Nanoparticles Nanomaterials composition Cancer Tested model Effects OR Involved mechanism Ref
Mn(III)-SS NEs Breast cancer 4T1 tumor-bearing mice ZCUNH synergize ferroptosis induction to boost immunotherapy by activating cGAS-STING pathway in osteosarcoma [36]

U-104,a novel carbonic anhydrase inhibitor