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. 2025 Aug 21;23:943. doi: 10.1186/s12967-025-06977-3

Table 2.

Overview of the number of subjects corresponding to each predicted optimal interventions, and the combinations of interventions that resulted in the maximal reduction of risk

Intervention # of subjects
MRA + Exercise + GLP1RA + SGLT2I + ARB 320
MRA + Exercise + GLP1RA + SGLT2I + Olive oil + ARB 165
MRA + SGLT2I + ARB 123
MRA + Exercise + SGLT2I + ARB 120
MRA + Exercise + ARB 48
MRA + Exercise + GLP1RA + ARB 39
MRA + GLP1RA + SGLT2I + ARB 31
MRA + ARB 16
MRA + GLP1RA + ARB 16
SGLT2I + ARB 15
Exercise + GLP1RA + ARB 8
ARB 4
GLP1RA + ARB 4
GLP1RA + SGLT2I + ARB 4
MRA + GLP1RA + SGLT2I 4
Exercise + GLP1RA + SGLT2I + ARB 2
GLP1RA + SGLT2I 2
Olive oil 2
MRA + Exercise + SGLT2I + Olive oil + ARB 2
MRA + SGLT2I 2
Exercise + GLP1RA + SGLT2I + Olive oil + ARB 1
Exercise + SGLT2I + ARB 1
GLP1RA 1
SGLT2I 1
MRA + Exercise + GLP1RA + SGLT2I 1
MRA + Exercise + SGLT2I 1
MRA + GLP1RA + Olive oil + ARB 1
MRA + SGLT2I + Olive oil + ARB 1

ARB angiotensin receptor blockers, GLP1RA Glucagon-like peptide-1 receptor agonist, MRA mineralocorticoid receptor antagonist, SGLT2I sodium-glucose co-transporter 2 inhibitor