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. Author manuscript; available in PMC: 2025 Aug 25.
Published in final edited form as: J Mol Biol. 2025 May 21;437(17):169226. doi: 10.1016/j.jmb.2025.169226

Figure 2.

Figure 2.

Variant locations in the T1 folded domain. The location of each variant is shown in the mature Kv1.3 (PDB 7SSX [50]). The native residue at the site of the specified variant is depicted as a spacefilled model. Residues within 4.5 Å of the variant are shown as sticks (intra- and intersubunit in pink and black, respectively). Blue sticks represent H-bonds, yellow sticks represent ion-ion interactions. CADD PHRED and Revel scores for each variant are shown beneath each structure and in Supplementary Table 1. Rendered with RasMol.