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. 2025 Aug 22;25:613. doi: 10.1186/s12876-025-04206-1

Table 2.

Treatment regimens of prednisolone, azathioprine, and mycophenolate mofetil across included studies

Study Prednisolone Starting At Week 1 Dose Tapering Schedule AZA Starting Dose Dose Changes Final Dose MMF Starting Dose Dose Changes Final Dose
Dalekos et al. [21] 0.5–1 mg/kg/day Tapered by 5 mg every other week starting from week 3 to week 10 then by 5 mg weekly from week 11 to week 14 then by 2.5 mg weekly thereafter up to complete withdrawal 50 mg started at week 3 Increased by 25 mg every 2 weeks from week 5 to week 8 then by 50 mg on week 9 150 mg 1 g started at week 1 Increased to 1.5 g on week 3 then to 2 g on week 4 2 g
Dalekos et al. [23] 0.5–1 mg/kg/day Tapered by 5 mg every other week starting from week 3 to week 10 then by 5 mg weekly from week 11 to week 14 then by 2.5 mg weekly thereafter up to complete withdrawal 50 mg started at week 3 Increased by 25 mg every 2 weeks from week 5 to week 8 then by 50 mg on week 9 150 mg 1 g started at week 1 Increased to 1.5 g on week 3 then to 2 g on week 4 2 g
Snijders et al. [19] 40 mg for patients < 80 kg and 60 mg for patients > 80 kg Tapered down to 15 mg over 5 weeks and then by 2.5 mg weekly over another 5 weeks then the patients were maintained on 5 mg from week 11 to the end of the study 50 mg started at week 5 Increased by 50 mg on week 7 100 mg 1 g started at week 5 Increased to 2 g on week 7 2 g
Zachou et al. [15] 0.5–1 mg/kg/day 5 mg per week till the dose of 15 mg and then the tapering rate was 2.5 mg per week according to the biochemical and clinical response until complete withdrawal 1.5 mg/kg/day Unclear 2 mg/kg/day 1 g/day Gradually increased to 1.5–2 g/day after 3 weeks 1.5–2 g daily

Abbreviations: AZA Azathioprine, MMF Mycophenolate Mofetil