Table 2.
Treatment regimens of prednisolone, azathioprine, and mycophenolate mofetil across included studies
| Study | Prednisolone Starting At Week 1 Dose | Tapering Schedule | AZA Starting Dose | Dose Changes | Final Dose | MMF Starting Dose | Dose Changes | Final Dose |
|---|---|---|---|---|---|---|---|---|
| Dalekos et al. [21] | 0.5–1 mg/kg/day | Tapered by 5 mg every other week starting from week 3 to week 10 then by 5 mg weekly from week 11 to week 14 then by 2.5 mg weekly thereafter up to complete withdrawal | 50 mg started at week 3 | Increased by 25 mg every 2 weeks from week 5 to week 8 then by 50 mg on week 9 | 150 mg | 1 g started at week 1 | Increased to 1.5 g on week 3 then to 2 g on week 4 | 2 g |
| Dalekos et al. [23] | 0.5–1 mg/kg/day | Tapered by 5 mg every other week starting from week 3 to week 10 then by 5 mg weekly from week 11 to week 14 then by 2.5 mg weekly thereafter up to complete withdrawal | 50 mg started at week 3 | Increased by 25 mg every 2 weeks from week 5 to week 8 then by 50 mg on week 9 | 150 mg | 1 g started at week 1 | Increased to 1.5 g on week 3 then to 2 g on week 4 | 2 g |
| Snijders et al. [19] | 40 mg for patients < 80 kg and 60 mg for patients > 80 kg | Tapered down to 15 mg over 5 weeks and then by 2.5 mg weekly over another 5 weeks then the patients were maintained on 5 mg from week 11 to the end of the study | 50 mg started at week 5 | Increased by 50 mg on week 7 | 100 mg | 1 g started at week 5 | Increased to 2 g on week 7 | 2 g |
| Zachou et al. [15] | 0.5–1 mg/kg/day | 5 mg per week till the dose of 15 mg and then the tapering rate was 2.5 mg per week according to the biochemical and clinical response until complete withdrawal | 1.5 mg/kg/day | Unclear | 2 mg/kg/day | 1 g/day | Gradually increased to 1.5–2 g/day after 3 weeks | 1.5–2 g daily |
Abbreviations: AZA Azathioprine, MMF Mycophenolate Mofetil