Table 3.

Adverse effects requiring treatment discontinuation in included studies

Study	MMF + Pred group	Total events	AZA + Pred group	Total events
Dalekos et al. [21]	None	0/32	Severe lower respiratory tract infection (n = 1) Severe herpes simplex virus stomatitis (n = 1) Leukopenia (n = 2) Thrombocytopenia (n = 1) Marked increase in hepatic transaminases (n = 4)	9/32
Dalekos et al. [23]	Intolerance (rash development) (n = 1) Severe infections (n = 4) Lymphoma (n = 1) Melanoma (n = 1)	7/183	Intolerance (myelotoxicity and hepatotoxicity) (n = 9) Severe infections (n = 3)	12/64
Snijders et al. [19]	Severe peripheral oedema (n = 1) Neutropenia (n = 1)	2/39	Malaise (n = 1) Drug-induced liver injury, fever and thrombocytopenia (n = 1) Influenza B pneumonia (n = 1) Mortality (n = 1) Severe gastrointestinal symptoms (nausea and vomiting) (n = 4)	8/31
Abbreviations: AZA Azathioprine, MMF Mycophenolate Mofetil, Pred Prednisolone