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. 2025 Aug 21;24:344. doi: 10.1186/s12933-025-02902-6

Table 1.

Demographic characteristics of individuals with MetS stratified by TyG-ABSI tertiles (weighted)

Variables Total (n = 12,813) T1 (lowest) (n = 4271) T2 (middle) (n = 4271) T3 (highest) (n = 4271) P-value
Age (years) 51.65 ± 16.95 45.18 ± 16.06 52.59 ± 16.45 57.17 ± 16.12 < 0.001
Gender (%) < 0.001
Male 7021 (54.80) 1788 (41.86) 2510 (58.77) 2723 (63.76)
Female 5792 (45.20) 2483 (58.14) 1761 (41.23) 1548 (36.24)
Race (%) < 0.001
Mexican American 2223 (17.35) 586 (13.72) 814 (19.06) 823 (19.27)
Other Hispanic 995 ( 7.77) 280 (6.56) 354 (8.29) 361 (8.45)
Non-Hispanic White 6131 (47.85) 1602 (37.51) 2110 (49.4) 2419 (56.64)
Non-Hispanic Black 2866 (22.37) 1632 (38.21) 787 (18.43) 447 (10.47)
Other race-including multi-racial 598 ( 4.67) 171 (4) 206 (4.82) 221 (5.17)
Marital status (%) < 0.001
Single 4750 (37.07) 1808 (42.33) 1463 (34.25) 1479 (34.63)
Married/living with partner 8063 (62.93) 2463 (57.67) 2808 (65.75) 2792 (65.37)
Education level (%) < 0.001
Below high school 3336 (26.04) 861 (20.16) 1131 (26.48) 1344 (31.47)
High school graduate 3234 (25.24) 1095 (25.64) 1072 (25.1) 1067 (24.98)
Above high school 6243 (48.72) 2315 (54.2) 2068 (48.42) 1860 (43.55)
PIR (%) < 0.001
< 1.3 4050 (31.61) 1268 (29.69) 1356 (31.75) 1426 (33.39)
1.3–3.5 5013 (39.12) 1694 (39.66) 1611 (37.72) 1708 (39.99)
≥ 3.5 3750 (29.27) 1309 (30.65) 1304 (30.53) 1137 (26.62)
Smoking status (%) < 0.001
Yes 6300 (49.17) 1697 (39.73) 2183 (51.11) 2420 (56.66)
No 6513 (50.83) 2574 (60.27) 2088 (48.89) 1851 (43.34)
Alcohol use (%) 0.059
Yes 9008 (70.30) 2942 (68.88) 3055 (71.53) 3011 (70.50)
No 3805 (29.70) 1329 (31.12) 1216 (28.47) 1260 (29.50)
Cancer (%) < 0.001
Yes 1289 (10.06) 293 (6.86) 429 (10.04) 567 (13.28)
No 11,524 (89.94) 3978 (93.14) 3842 (89.96) 3704 (86.72)
CKD (%) < 0.001
Yes 386 ( 3.01) 82 (1.92) 123 (2.88) 181 (4.24)
No 12,427 (96.99) 4189 (98.08) 4148 (97.12) 4090 (95.76)
BMI(kg/m2) 34.98 ± 6.10 37.17 ± 6.71 34.56 ± 5.54 33.21 ± 5.26 < 0.001
Energy intake, M (Q1, Q3) 1884(1271, 2565) 1878(1254.50, 2560.50) 1908(1263, 2583) 1877(1295, 2545.50) 0.63
HDL-C (mg/dL) 47.74 ± 13.40 52.15 ± 13.37 47.81 ± 12.92 43.27 ± 12.40 < 0.001
LDL-C (mg/dL) 115.93 ± 35.48 116.04 ± 34.97 116.78 ± 35.52 114.97 ± 35.94 0.061
BUN (mg/dL) 13.87 ± 6.13 12.59 ± 5.04 14.04 ± 5.93 14.98 ± 7.02 < 0.001
UA (mg/dL) 5.92 ± 1.44 5.69 ± 1.36 6.03 ± 1.42 6.05 ± 1.50 < 0.001
Cr (mg/dL) 0.92 ± 0.38 0.88 ± 0.34 0.93 ± 0.42 0.95 ± 0.38 < 0.001
ALT, M (Q1, Q3) 23.00 (17.00, 32.00) 21.00 (16.00, 29.00) 24.00 (18.00, 33.00) 24.00 (18.00, 34.00) < 0.001
AST, M (Q1, Q3) 23.00 (19.00, 28.00) 22.00 (18.00, 27.00) 23.00 (20.00, 28.00) 24.00 (20.00, 30.00) < 0.001
ALB (g/dL) 4.14 ± 0.35 4.10 ± 0.34 4.16 ± 0.34 4.15 ± 0.37 < 0.001
TBil, M (Q1, Q3) 0.60 (0.50, 0.90) 0.60 (0.50, 0.80) 0.70 (0.50, 0.90) 0.60 (0.50, 0.90) < 0.001
TG, M (Q1, Q3) 147.00 (100.00, 219.00) 92.00 (71.00, 121.00) 147.00 (114.00, 191.00) 240.00 (178.00, 334.50) < 0.001
FBG (mg/dl) 107.81 ± 40.92 93.59 ± 15.48 101.14 ± 23.99 128.68 ± 59.38 < 0.001
TC (mg/dL) 196.02 ± 43.14 186.49 ± 37.18 195.58 ± 40.40 205.97 ± 48.78 < 0.001
Antidiabetic medication use (%) < 0.001
No 12,314 (96.11) 4221 (98.83) 4141 (96.96) 3952 (92.53)
Yes 499 ( 3.89) 50 (1.17) 130 (3.04) 319 (7.47)
Statin use (%) < 0.001
No 9922 (77.44) 3709 (86.84) 3291 (77.05) 2922 (68.41)
Yes 2891 (22.56) 562 (13.16) 980 (22.95) 1349 (31.59)
Antihypertensive use (%) < 0.001
Yes 11,147 (87.00) 3637 (85.16) 3711 (86.89) 3799 (88.95)
No 1666 (13.00) 634 (14.84) 560 (13.11) 472 (11.05)
CVD(%) < 0.001
No 11,173 (87.20) 3944 (92.34) 3740 (87.57) 3489 (81.69)
Yes 1640 (12.80) 327 (7.66) 531 (12.43) 782 (18.31)
All-cause mortality (%) < 0.001
No 11,063 (86.34) 3946 (92.39) 3708 (86.82) 3409 (79.82)
Yes 1750 (13.66) 325 (7.61) 563 (13.18) 862 (20.18)
Cardiovascular mortality (%) < 0.001
No 12,268 (95.75) 4176 (97.78) 4094 (95.86) 3998 (93.61)
Yes 545 ( 4.25) 95 (2.22) 177 (4.14) 273 (6.39)

MetS: metabolic syndrome; TyG-ABSI: triglyceride-glucose and a body shape index; CVD: cardiovascular disease; PIR: family poverty-to-income ratio; BMI: body mass index; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; BUN: blood urea nitrogen; UA: uric acid; Cr: creatinine; ALT: alanine aminotransferase; AST: aspartate transaminase; ALB: albumin; TBil: total bilirubin; TG: triglyceride; FBG: fasting blood glucose; CKD: chronic kidney disease; M: median; Q1: 1st quartile; Q3: 3rd quartile