Table 1.
Post-translational modifications of characteristic protein families and related signaling pathways
| Name and expression changes | Check out location | Type | Molecular Mechanism | Post-translational modifications | Role in Cell Phenotypes or Behavior | Refs. | |
|---|---|---|---|---|---|---|---|
| S100 | S100A9↓ | Human tissue | CRA | PI3K/AKT, MAPK/ERK | / | Cell proliferation | [13] |
| S100A10↑ | Human tissue/Mouse tissue | FAP | Wnt/β-catenin | / | Cell proliferation, Migration | [58] | |
| S100A11↑ | Human tissue/Mouse tissue | CRA | TGF-β | Ubiquitination | Cell migration, EMT | [11] | |
| S100P↑ | Human tissue | CRA | Wnt/β-catenin, ERK | / |
Cell cycle, Cell migration |
[12] | |
| MUC | MUC1↑ | Human tissue | CRA | JAK/STAT | Glycosylation | Cancer progression, EMT | [27] |
| MUC2↓ |
Human tissue/ feces |
CRA, SL |
NF-κB |
Sulfation、 Methylation |
Cell proliferation Migration, Apoptosis | [28] | |
| MUC4↓ | Human tissue/Mouse tissue | CRA | Wnt/β-catenin, TGF-β, PI3K/AKT | Glycosylation | Cell migration | [26] | |
| MUC5AC↑ |
Human tissue/ feces |
CRA, SL |
Wnt/β-catenin |
Glycosylation、 Methylation |
Cell proliferation, Apoptosis, Immune escape | [28, 47] | |
| ANXA | ANXA3↑ | Human tissue | CRA | HIF-1α | / |
Cell proliferation, Migration, Drug resistance |
[10] |
| ANXA6 | Human feces | CRA | MAPK, PI3K-Akt | / | Cell proliferation, Apoptosis | [40] | |
| ANXA10↑ | Mouse tissue | SL | TGF-β | / |
Cell proliferation, Migration, Iron death |
[49] | |
| HSP | HSP47↑ | Human tissue | CRA | Wnt/β-catenin, TGF-β | / | Stress response, Proliferation, Apoptosis, Migration | [21] |
| HSP70↑ | Mouse tissue | SL, FAP | PI3K/AKT | / | Cell proliferation, Migration | [56] | |