Table 2.
Expression and role of the same protein in different types of precancerous lesions
| Name and expression changes | Check out location | Type | Molecular Mechanism | Role in Cell Phenotypes or Behavior | Refs. |
|---|---|---|---|---|---|
| MUC2↓ |
Tissue, Stool samples from patients with adenoma |
CRA, SL |
NF-κB | Cell proliferation Migration, Apoptosis | [28] |
| MUC5AC↑ | Tissue, Stool samples from patients with adenoma |
CRA, SL |
Wnt/β-catenin | Cell proliferation, Apoptosis, Immune escape | [28, 47] |
| HSP70↑ | Tissue | SL, FAP | PI3K/AKT | Cell proliferation, Migration | [56] |
| β-catenin↑ | Tissue |
CRA, SL, LST, FAP, IBD |
Wnt/β-catenin | Cell proliferation, Migration | [15, 58, 59] |
| RUNX3↓ | Tissue |
CRA, LST |
TGF-β, Wnt/β-catenin | Cell proliferation, Migration | [46] |
| LGR5↑ | Tissue |
CRA, LST |
Wnt/β-catenin | EMT | [53] |