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. 2025 Aug 21;19(1):246. doi: 10.1186/s13065-025-01607-x

Table 3.

Analysis of laboratory prepared mixture of RDV and MFX by the proposed methods

Method Laboratory prepared mixture (µg/mL) % Recovery*
RDV MFX RDV MFX
Ratio derivative 1 2 98.18 98.96
1 4 100.78 99.13
2 4 100.32 100.87
2 8 99.03 101.02
4 4 101.72 99.13
Mean ± %RSD 100.01 ± 1.406 99.82 ± 1.033
Ratio difference 1 2 101.77 99.65
1 4 100.08 101.55
2 4 100.71 98.37
2 8 101.67 101.08
4 4 99.98 98.14
Mean ± %RSD 100.84 ± 0.842 99.76 ± 1.547
Mean centering 1 2 101.38 100.79
1 4 99.36 101.86
2 4 100.42 98.72
2 8 101.50 100.98
4 4 99.48 98.12
Mean ± %RSD 100.43 ± 1.007 100.10 ± 1.593

Area under

curve

1 2 98.55 101.51
1 4 100.36 98.18
2 4 99.88 98.50
2 8 100.06 99.02
4 4 98.27 100.76
Mean ± %RSD 99.42 ± 0.952 99.59 ± 1.468

Q-

analysis

1 2 102.08 99.75
1 4 99.71 100.80
2 4 100.70 98.71
2 8 101.10 101.32
4 4 100.90 100.91
Mean ± %RSD 100.90 ± 0.844 100.30 ± 1.053
Bivariate 1 2 98.48 98.76
1 4 98.87 101.88
2 4 101.63 101.30
2 8 98.76 100.92
4 4 99.72 100.22
Mean ± %RSD 99.29 ± 0.887 100.62 ± 1.191

* Average of three determinations