Table 6.
Statistical study and determination of RDV and MFX in pharmaceutical formulations using the proposed spectrophotometric and previously described methods
| Parameters | RDV | MFX | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1DD | RD | MC | AUC | Q-analysis | Bivariate | Reported method [15] | 1DD | RD | MC | AUC | Q-analysis | Bivariate | Reported method [36] | |
| Number of measurements | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| Mean % Recovery | 100.42 | 99.73 | 98.94 | 100.15 | 99.14 | 98.90 | 99.79 | 99.35 | 100.81 | 99.19 | 98.56 | 99.96 | 100.96 | 99.49 |
| % RSD | 1.142 | 1.213 | 0.792 | 1.958 | 0.922 | 0.688 | 1.197 | 1.046 | 0.893 | 0.877 | 0.539 | 0.601 | 1.054 | 1.496 |
| Variance | 1.316 | 1.463 | 0.616 | 3.845 | 1.427 | 0.463 | 1.427 | 0.172 | 0.811 | 0.756 | 0.282 | 0.361 | 1.132 | 2.216 |
| Student’s t-test * (2.447) | 0.761 | 0.084 | 1.183 | 0.311 | 0.861 | 1.292 | —— | 1.375 | 1.521 | 0.347 | 1.178 | 0.591 | 1.607 | —— |
| F-value* (9.277) | 1.085 | 1.024 | 2.320 | 2.693 | 1.708 | 3.087 | —— | 2.050 | 2.732 | 2.929 | 7.855 | 6.131 | 1.957 | —— |
* The values in parenthesis are tabulated values of “t ” and “F ” at (p = 0.05) [69]