Table 6.
The physico-chemical properties of the synthesized compounds
| Code | Lipophilicity consensus log P | Physico-chemical properties | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MWa g/mol |
Heavy Atoms | Aromatic heavy atoms |
Rot. bond | H acceptor bond |
H donor bond |
MRb | TPSAc (A2) | % ABSd | Colour | ||
| 4a | 1.50 | 375.42 | 27 | 11 | 5 | 7 | 1 | 105.29 | 94.11 | 76.53 | White |
| 4b | 2.73 | 403.48 | 29 | 11 | 7 | 7 | 1 | 114.90 | 94.11 | 76.53 | White |
| 4c | 2.75 | 451.52 | 33 | 17 | 7 | 7 | 1 | 129.77 | 94.11 | 76.53 | White |
| 4d | 2.95 | 465.54 | 34 | 17 | 7 | 7 | 1 | 134.74 | 94.11 | 76.53 | White |
| 4e | 2.80 | 481.54 | 35 | 17 | 8 | 8 | 1 | 136.27 | 103.34 | 73.34 | White |
| 4f | 3.15 | 485.96 | 34 | 17 | 7 | 7 | 1 | 134.78 | 94.11 | 76.53 | White |
| 4 g | 2.66 | 437.49 | 32 | 17 | 6 | 7 | 1 | 125.76 | 94.11 | 76.533+ | White |
aMW, molecular weight; cTPSA, topological polar surface area; bMR, molar refractivity; dABS%: absorption percent