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Stability of alectinib in rat plasma (mean ± SD, n = 3)
| Storage condition | Stability (%, mean ± SD)a | |
|---|---|---|
| LQC (15 ng/mL) | HQC (800 ng/mL) | |
| Bench top (room temperature for 2 h) | 110 ± 10 | 109 ± 2 |
| Long term (-20 °C for 3 weeks) | 104 ± 9 | 110 ± 6 |
| Freeze-thaw (3 cycles) | 87.3 ± 9.5 | 100 ± 6 |
| Post-preparation stability (10 °C for 24 h) | 93.8 ± 6.4 | 95.7 ± 3.4 |
a Stability (%) = measured concentration after the designated storage condition/nominal concentration × 100
