Table 7.
Pharmacokinetic parameters of alectinib after intravenous or oral administration to rats (mean ± SD, n = 3)
| Parameter | PO (10 mg/kg) | IV (10 mg/kg) |
|---|---|---|
| C0 (ng/mL) | - | 8,390 ± 160 |
| Cmax (ng/mL) | 224 ± 1 | - |
| Tmax (h) | 3 ± 0 | - |
| T1/2 (h) | 10.2 ± 0.1 | 6.15 ± 0.08 |
| AUClast (ng∙h/mL) | 4,040 ± 20 | 31,000 ± 800 |
| AUCinf (ng∙h/mL) | 4,200 ± 10 | 31,100 ± 800 |
| CL (mL/h/kg) | - | 129 ± 3 |
| Vss (mL/kg) | - | 1,010 ± 20 |
| Bioavailability (%) | 13.5 ± 0.3 | - |
a Calculated using the dose-normalized AUCPO / dose-normalized AUCIV × 100
AUC, area under the plasma concentration-time curve; CL, total clearance; Cmax, maximum plasma concentration; MRT, mean residence time; SD, standard deviation; T1/2, terminal half-life; Tmax, time to reach Cmax; Vss, steady-state volume of distribution