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. 2025 Aug 22;14:90. doi: 10.1186/s13741-025-00571-3

Table 1.

Between-group differences in preoperative, intraoperative, and postoperative data

Characteristics PS (N = 23) MS (N = 27) MK (N = 24) PK (N = 30) p-value
Sex Male 16 (69.57%) 12 (44.44%) 12 (50.0%) 13 (43.33%) 0.226
Female 7 (30.43%) 15 (55.56%) 12 (50.0%) 17 (56.67%)
Employment Not working 8 (34.78%) 13 (48.14%) 13 (54.17%) 13 (43.33%) 0.446
Active worker 4 (17.39%) 4 (14.81%) 5 (20.83%) 10 (33.33%)
Retired 10 (43.48%) 7 (25.93%) 6 (25.0%) 5 (16.67%)
Chemotherapy 9 (39.13%) 12 (44.44%) 10 (41.67%) 14 (46.67%) 0.930
Radiotherapy 10 (43.48%) 11 (25%) 10 (41.67%) 14 (46.67%) 0.978
Married 4 (17.39%) 1 (3.7%) 2 (8.33%) 4 (13.33%) 0.408

PS, placebo-saline; MS, melatonin-saline; MK, melatonin-ketamine; PK, placebo-ketamine