Table 5.
POD incidence, POD severity, and pain severity
| Effect | Estimate | SE | p-value |
|---|---|---|---|
| POD incidence (CAM-ICU) | |||
| Group | 0.23 | - | 0.8769 |
| Time | 3.16 | - | 0.0016 |
| Surgery duration | 0.22 | - | 0.6398 |
| POD severity (CAM-ICU-7) | |||
| Group PS | − 0.1245 | 0.1194 | 0.3002 |
| Group MS | − 0.1471 | 0.1202 | 0.2249 |
| Group MK | − 0.1193 | 0.1154 | 0.3045 |
| Group PK | 0 | ||
| Surgery night | 1.3000 | 0.2067 | <.0001 |
| 1 st day | 0.5375 | 0.1302 | <.0001 |
| 1 st night | 0.3750 | 0.1507 | 0.0151 |
| 2nd day | 0.1875 | 0.1095 | 0.0911 |
| 2nd night | 0.02498 | 0.09727 | 0.7980 |
| 3rd day | 0.07498 | 0.07305 | 0.3080 |
| 3rd night | 0.05192 | 0.09597 | 0.5901 |
| 4th day | 0.01256 | 0.03786 | 0.7409 |
| 4th night | 0 | ||
| Pain severity (VAS) | |||
| Group PS | − 0.2702 | 0.4799 | 0.5751 |
| Group MS | 0.8843 | 0.4832 | 0.0712 |
| Group MK | 0.2680 | 0.4634 | 0.5648 |
| Group PK | 0 | ||
| Surgery night | 2.3720 | 0.4890 | <.0001 |
| 1 st day | 2.8285 | 0.3905 | <.0001 |
| 1 st night | 1.9660 | 0.4911 | 0.0001 |
| 2nd day | 1.0535 | 0.4041 | 0.0110 |
| 2nd night | 0.7660 | 0.4025 | 0.0609 |
| 3rd day | 0.5535 | 0.3369 | 0.1047 |
| 3rd night | 0.5694 | 0.3765 | 0.1346 |
| 4th day | 0.02052 | 0.3021 | 0.9460 |
| 4th night | 0 | ||
PS, placebo-saline; MS, melatonin-saline; MK, melatonin-ketamine; PK, placebo-saline; CAM, Confusion Assessment Method; VAS, visual analogue scale