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. 2025 Jul 23;17(7):e88575. doi: 10.7759/cureus.88575

Figure 2. Angiocentric glioma, CNS WHO Grade 1.

Figure 2

(A) Smear preparation reveals bipolar cells (arrows) with long processes, resembling pilocytic astrocytoma (Hematoxylin and Eosin, 200x). (B) At low magnification, the tumor shows mostly parallel neoplastic bipolar cells arranged in a distinctive angiocentric pattern, (arrows) (H&E, 100x). (C) The myxoid component is markedly hypocellular but retains the angiocentric configuration (arrows) (H&E, 100x). (D) Tumor cells show diffuse GFAP expression, particularly highlighting the angiocentric pattern (GFAP, polyclonal, Ventana, 200x). (E) Strong D2-40 expression is seen in tumor cells (arrows) (clone D2-4, DakoCytomation, 400x). (F) EMA shows moderate cytoplasmic staining, with perinuclear accentuation noted in some cells (arrows) (EMA, clone E29, Dako, 400x).

Image Source: Almubarak et al. [27] shared under the Creative Commons CC BY-NC license

GFAP: Glial fibrillary acidic protein; EMA: Epithelial membrane antigen